Chinese scientists have discovered a new bat coronavirus capable of infecting humans, sparking concerns about another potential pandemic.
At a Glance
- HKU5-CoV-2, a new bat coronavirus, has been discovered in China
- The virus targets the same human receptor as SARS-CoV-2
- It can infect human cells and artificially grown tissues
- The research was led by Zheng-Li Shi, known as “batwoman”
- Current risk assessment deems the pandemic potential as “very low”
New Bat Coronavirus Discovery
A team of Chinese researchers, led by Zheng-Li Shi from the Guangzhou Laboratory, has identified a new bat coronavirus named HKU5-CoV-2. This discovery has reignited discussions about the potential risks of another pandemic. The virus, which belongs to the merbecovirus subgenus, shares similarities with SARS-CoV-2, the virus responsible for the COVID-19 pandemic.
The study, published in the journal Cell, highlights the zoonotic risk of HKU5-CoVs in bats. Researchers from the Guangzhou Academy of Sciences, Wuhan University, and the Wuhan Institute of Virology contributed to this significant finding. The discovery underscores the importance of continued surveillance and research into potential zoonotic threats.
One of the most concerning aspects of HKU5-CoV-2 is its ability to target the human ACE2 receptor, the same entry point used by SARS-CoV-2. Laboratory tests have shown that the virus can infect human cell cultures and artificially grown lung and intestine tissues.
“Bat merbecoviruses, which are phylogenetically related to MERS-CoV, pose a high risk of spillover to humans, either through direct transmission or facilitated by intermediate hosts,” the study stated.
This capability raises concerns about the potential for human-to-human or cross-species transmission. However, experts caution against overreacting to this discovery, as the virus’s ability to cause disease in humans remains unconfirmed.
Risk Assessment and Expert Opinions
Despite the alarming similarities to SARS-CoV-2, the current risk assessment for HKU5-CoV-2 causing a pandemic is considered “very low.”
At least, for now.
This evaluation is based on the virus’s weaker binding affinity and lower potency compared to SARS-CoV-2.
Dr. Michael Osterholm, an infectious disease expert, suggested that the risk of another pandemic from this virus is likely overblown due to existing immunity to similar viruses in human populations. Nevertheless, the study advises caution and continued monitoring of the situation.
The discovery of HKU5-CoV-2 serves as a reminder of the persistent threats posed by zoonotic viruses. Just because the 2020 pandemic is over doesn’t mean it can’t happen again. It can…
